Anti-p21 Rabbit antibody

Cat.#: 167193

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-p21 Rabbit antibody
  • Documents
  • Description
    p21 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC, IP
  • Species reactivity
    Mouse
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of mouse p21
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    IHC: 1/200

    ICC/IF: 1/100

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of p21 in Raw264.7 cell lysates using p21 Rabbit pAb(1:1000 diluted).Predicted band size:18KDa.Observed band size:18KDa.

    Western blot detection of p21 in Raw264.7 cell lysates using p21 Rabbit pAb(1:1000 diluted).Predicted band size:18KDa.Observed band size:18KDa.

  • Background
    Swiss-Prot Acc.P39689.May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding .

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"