Human CD47 recombinant protein (C-His)

Human CD47 recombinant protein (C-His)

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CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.Immune Checkpoint
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Leukocyte surface antigen CD47

IAP,MER6,OA3

Q08722

Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD antigen CD47

Human Cells

A DNA sequence encoding the human CD47 (NP_942088.1) (Met1-Pro139) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human CD47 consists of 132 amino acids and predicts a molecular mass of 15.2 kDa.

> 95 % as determined by SDS-PAGE.