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Product Name
Human CD31/PECAM-1 recombinant protein
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Description
The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. CD31 protein is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies. CD31 plays a key role in removing aged neutrophils and tissue regeneration. CD31 protein mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development.
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Protein name
Platelet endothelial cell adhesion molecule
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Protein short names
GPIIA'; ENDOCAM; C85791; CD31; CD31/ENDOCAM; PECAM-1; PECA1; PECAM; PECAM1
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Uniprot ID
P16284
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Gene Name
PECAM1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
The mature form of human CD31 (EAW94208.1) extracellular domain (Met1-Lys 601) with five additional amino acids (DDDDK) at the C-terminus was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human CD31 consists of 580 amino acids and has a predicted molecular mass of 65.1 kDa. As a result of glycosylation, the molecular mass of rhCD31 is approximately 115 kDa in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human CD31 / PECAM1 Protein SDS-PAGE
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