Human CD116/GM-CSFR (Fc Tag) recombinant protein

Human CD116/GM-CSFR (Fc Tag) recombinant protein

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CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

P15509

CSF2RA; CSF2R; CSF2RY

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Gly 320) of human GM-CSFR? (NP_006131.2) pro-protein was expressed with the C-terminal fused Fc region of human IgG1.

Human

The recombinant human GM-CSFR? consists of 536 amino acids and has a predicted molecular mass of 61.2 kDa.

> 90 % as determined by SDS-PAGE

Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is typically 10-15 μg/ml.