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Product Name
Mouse HDAC8 (His Tag) recombinant protein
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Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity).
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Protein name
Histone deacetylase 8
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Protein short names
RPD3; RP23-331B22.1; 2610007D20RIK; WTS; HD8; HDAC8; CDLS5; MRXS6; CDA07; HDACL1
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Uniprot ID
Q8VH37
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Gene Name
Hdac8
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse HDAC8 isoform 1 (Q8VH37-1) (Met 1-Val 377) was expressed?with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse HDAC8 consists of 387 amino acids and has a calculated molecular mass of 43.1 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse HDAC8 / HDACL1 Protein (His Tag) SDS-PAGE
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