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Product Name
Anti-HDAC8 Rabbit antibody
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Description
HDAC8 Rabbit polyclonal antibody
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Tested applications
WB, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human HDAC8
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
FC: 1/20
IP: 1/20
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Validations
Western blot detection of HDAC8 in K562 cell lysates using HDAC8 Rabbit pAb(1:1000 diluted).Predicted band size:42kDa.Observed band size:42kDa.
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Background
Swiss-Prot Acc.Q9BY41.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"