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Product Name
Mouse Growth Hormone Receptor / GHR / GHBP (His & Fc Tag) recombinant protein
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Description
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
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Protein name
Growth hormone receptor
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Protein short names
GROWTH HORMONE RECEPTOR; GHR; AA986417; GHBP; GHR/BP; GHIP
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Uniprot ID
Q3UP14
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Gene Name
Ghr
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Gln 273) of mouse GHR (NP_034414.2) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse GHR/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 497 amino acids and has a predicted molecular mass of 56.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmGHR/Fc monomer is approximately 70-80 kDa due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Mouse Growth Hormone Receptor / GHR / GHBP Protein (His & Fc Tag) SDS-PAGE
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