Anti-Growth Hormone Receptor / GHR / GHBP antibody

Cat.#: 106160

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Product Information

  • Product Name
    Anti-Growth Hormone Receptor / GHR / GHBP antibody
  • Documents
  • Description
    Rabbit monoclonal to Growth Hormone Receptor / GHR / GHBP
  • Tested applications
    IHC-P
  • Species reactivity
    Mouse Growth Hormone Receptor / GHR / GHBP
  • Alternative names
    GHBP antibody; GHIP antibody; GHBP antibody; GHR/BP antibody; AA986417 antibody; GHBP antibody; GHBP antibody; Ghr antibody; GHR antibody; GHR/BP antibody; Growth Hormone Receptor antibody; Growth Hormone Receptor antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Growth Hormone Receptor / GHR / GHBP (rM Growth Hormone Receptor / GHR / GHBP; NP_034414.2; Met1-Gln273).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 10-20 μg/mL

  • Validations

    Growth Hormone Receptor / GHR / GHBP Antibody, Rabbit MAb, Immunochemistry

    Growth Hormone Receptor / GHR / GHBP Antibody, Rabbit MAb, Immunochemistry

    Immunochemical staining of mouse GHR in mouse kidney with rabbit monoclonal antibody (10 µg/mL, formalin-fixed paraffin embedded sections).

    Growth Hormone Receptor / GHR / GHBP Antibody, Rabbit MAb, Immunochemistry

    Growth Hormone Receptor / GHR / GHBP Antibody, Rabbit MAb, Immunochemistry

    Immunochemical staining of mouse GHR in mouse stomach with rabbit monoclonal antibody (10 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
  • References
    • Leung DW. et al., 1987, Nature. 330:537-43.
    • Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
    • Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
    • Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
    • Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"