Anti-Growth Hormone Receptor / GHR / GHBP antibody

Anti-Growth Hormone Receptor / GHR / GHBP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to Growth Hormone Receptor / GHR / GHBP

IHC-P

Mouse Growth Hormone Receptor / GHR / GHBP

GHBP antibody; GHIP antibody; GHBP antibody; GHR/BP antibody; AA986417 antibody; GHBP antibody; GHBP antibody; Ghr antibody; GHR antibody; GHR/BP antibody; Growth Hormone Receptor antibody; Growth Hormone Receptor antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Growth Hormone Receptor / GHR / GHBP (rM Growth Hormone Receptor / GHR / GHBP; NP_034414.2; Met1-Gln273).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

• Leung DW. et al., 1987, Nature. 330:537-43.
• Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
• Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
• Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
• Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.