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Product Name
Human GFRA2 (His Tag) recombinant protein
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Description
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
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Protein name
GDNF family receptor alpha-2
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Protein short names
GFRA2; GDNF RECEPTOR ALPHA-2; NRTNR-ALPHA; NTNRA; GDNF FAMILY RECEPTOR ALPHA-2; TRNR2; GDNFR-BETA; TGF-BETA-RELATED NEUROTROPHIC FACTOR RECEPTOR 2; NTNR-ALPHA; GDNF RECEPTOR BETA; GDNFR-ALPHA-2; GDNFRB; RETL2; GFR ALPHA 2; NEURTURIN RECEPTOR ALPHA
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Uniprot ID
O00451
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Gene Name
GFRA2; GDNFRB; RETL2; TRNR2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human GFR?2 (NP_001486.4) without the propeptide (Met 1-Ser 441) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GFR?2 consists of 431 amino acids after removal of the signal peptide and predicts a molecular mass of 48.2 kDa. As a result of glycosylation, the apparent molecular mass of rhGFR?2 is approximately 60-70 kDa in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Validations
Human GFRA2 / GFR?2 / GDNFRB Protein (His Tag) SDS-PAGE
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