Anti-GFRA2 antibody

Anti-GFRA2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to GFRA2

WB

Human GFRA2

GDNF family receptor alpha-2 antibody; GDNF receptor alpha-2 antibody; GDNF receptor beta antibody; GDNFR-alpha-2 antibody; GDNFRB antibody; GDNFR-beta antibody; GFR alpha 2 antibody; Gfra2 antibody; GFRA2 antibody; neurturin receptor alpha antibody; NRTNR-alpha antibody; NRTNR-ALPHA antibody; NTNRA antibody; NTNR-alpha antibody; RETL2 antibody; TGF-beta-related neurotrophic factor receptor 2 antibody; TRNR2 antibody; NTNRA antibody; RETL2 antibody; TRNR2 antibody; GDNFRB antibody; NRTNR-ALPHA antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA2 (rh GFRA2; NP_001486.4; Met1-Ser441).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings.

• Jing S, et al. (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 272(52): 33111-7.
• Souza RP, et al. (2010) Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia. Psychopharmacology. 210(3): 347-54.
• Vanhorne JB, et al. (2001) Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Hum Genet. 108(5): 409-15.