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Human GFRA1 (His Tag) recombinant protein

Cat.#: 501004

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Product Information

  • Product Name
    Human GFRA1 (His Tag) recombinant protein
  • Documents
  • Description
    Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
  • Protein name
    GDNF family receptor alpha-1
  • Protein short names
    AU042498; MGC23045; RET1L; GFRA1; DKFZP313E1012; RETL1; TRNR1; GDNFRA; GDNFR; DKFZP686J0156; FLJ31546; GFR-ALPHA-1; FLJ10561
  • Uniprot ID
    P56159
  • Gene Name
    GFRA1; GDNFRA; RETL1; TRNR1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human GFR?1 without the propeptide (NP_665736.1) (Met 1-Ser 424) was fused with the a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human GFR?1 consists of 411 amino acids after removal of the signal peptide and predicts a molecular mass of 46 kDa. As a result of glycosylation, the rhGFR?1 migrates as an approximately 55-60 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    1. Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 0.2-1 μg/mL in the presence of 40 ng/mL Recombinant Human GDNF.
    2. Measured by its ability to bind human GDNF (native) in functional ELISA.
  • Validations

    Human GFRA1 / GFR?1 / GDNFRA Protein (His Tag) SDS-PAGE

    Human GFRA1 / GFR?1 / GDNFRA Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"