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Product Name
Rat GFRA1 (His Tag) recombinant protein
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Description
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
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Protein name
GDNF family receptor alpha-1
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Protein short names
RET1L; MGC23045; AU042498; RETL1; DKFZP313E1012; GFRA1; GDNFR; GDNFRA; TRNR1; FLJ31546; GFR-ALPHA-1; FLJ10561; DKFZP686J0156
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Uniprot ID
Q62997
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Gene Name
Gfra1; Gdnfra; Retl1; Trnr1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat GFRA1 (Q62997-1) (Met 1-Leu 445) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat GFRA1 comprises 432 amino acids and predicts a molecular mass of 48 kDa. The apparent molecular mass of the rat GFRA1 is approximately 58-65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells.
The ED50 for this effect is typically 0.2-1 μg/mL in the presence of 40 ng/mL Recombinant Rat GDNF. -
Validations
Rat GFRA1 / GFR alpha-1 Protein (His Tag) SDS-PAGE
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