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Product Name
Mouse FOLR1 / Folate Receptor 1 (His Tag) recombinant protein
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Description
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.
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Protein name
Folate receptor alpha
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Protein short names
FOLR1; FOLBP1; FBP1; FOLR; FBP; FOLBP-1
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Uniprot ID
P35846
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Gene Name
Folr1; Fbp1; Folbp1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse FOLR1 (NP_032060.2) (Met 1-Met 231) without the pro peptide was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse FOLR1 consists of 218 amino acids and has a predicted molecular mass of 25.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmFOLR1 is approximately 33-37 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse FOLR1 / FR-alpha Protein (His Tag) SDS-PAGE
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