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Product Name
Human 4E-BP1/EIF4EBP1 (His Tag) recombinant protein
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Description
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
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Protein name
Eukaryotic translation initiation factor 4E-binding protein 1
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Protein short names
MGC4316; 4EBP1; AA959816; EIF4EBP1; PHAS-I; 4E-BP1; BP-1
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Uniprot ID
Q13541
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Gene Name
EIF4EBP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human 4EBP1 (NP_004086.1) (Ser 2-Ile 118) with a N-terminal polyhistidine tag was expressed.
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Protein Species
Human
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Molecular weight
The secreted recombinant human 4EBP1 comprises 124 amino acids with a predicted molecular mass of 13.4 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human 4E-BP1 / EIF4EBP1 Protein (His Tag) SDS-PAGE
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