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Product Name
Mouse ENPP7 (His Tag) recombinant protein
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Description
Mouse Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.
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Protein name
Enpp7 protein
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Protein short names
GM254; ENPP7; MGC50179; ALK-SMASE; RP23-386D6.4; NPP7; E-NPP7; NPP-7
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Uniprot ID
Q3TIW9
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Gene Name
Enpp7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse ENPP7 (Q3TIW9) (Met 1-Gln 421) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse ENPP7 consists of 411 amino acids and has a calculated molecular mass of 47 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse ENPP7 / NPP-7 Protein (His Tag) SDS-PAGE
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