Anti-ENPP7 antibody

Anti-ENPP7 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to ENPP7

ELISA, WB

Human ENPP7 / NPP-7

NPP7 antibody; NPP-7 antibody; E-NPP7 antibody; ALK-SMase antibody; Gm254 antibody; Alk-SMase antibody; ALK-SMase antibody; Alk-SMase antibody; ENPP7 antibody; Enpp7 antibody; Gm254 antibody; MGC50179 antibody; RP23-386D6.4 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human ENPP7 / NPP-7 (rh ENPP7; NP_848638.2; Met 1-Ser 439). ENPP7 specific IgG was purified by human ENPP7 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Mouse Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.

• Wu J. et al., 2005, Biochem. J. 386:153-60.
• Wu J. et al., 2004, Carcinogenesis 25:1327-33.
• Duan R.-D. et al., 2003, J. Lipid Res. 44:1241-50.
• Duan R.-D. et al., 2003, J. Biol. Chem. 278:38528-36.