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Product Name
Human DSC2 (His Tag) recombinant protein
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Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
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Protein name
Desmocollin-2
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Protein short names
DSC2A; ARVD11; DSC3; DGII/III; DG2; DSC2; AW228162; DKFZP686I11137; CDHF2; DSC2B
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Uniprot ID
Q02487
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Gene Name
DSC2; CDHF2; DSC3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Arg 684) of human DSC2 (Q02487-1) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human DSC2 (pro form) consists of 668 amino acids and predicts a molecular mass of 75 kDa. As a result of glycosylation, the apparent molecular mass of rhDSC2 is approximately 85 and 100 kDa in SDS-PAGE under reducing conditions, corresponding to the mature and pro form respectively.
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Purity
> 75 % as determined by SDS-PAGE
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Validations
Human DSC2 / Desmocollin-2 Protein (His Tag) SDS-PAGE
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