Anti-DSC2 antibody

Anti-DSC2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Monoclonal to Rat DSC2

IHC-P

Rat DSC2

ARVD11 antibody; AW228162 antibody; CDHF2 antibody; DG2 antibody; DGII/III antibody; DKFZp686I11137 antibody; DSC2 antibody; Dsc2 antibody; Dsc2a antibody; DG2 antibody; Dsc2b antibody; DSC3 antibody; CDHF2 antibody; ARVD11 antibody; DGII/III antibody; Dsc2a antibody; Dsc2b antibody; AW228162 antibody; DSC3 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Rat DSC2 .

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms.