Cynomolgus IL-21R (Fc Tag) recombinant protein

Cynomolgus IL-21R (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.

Interleukin-21 receptor

MGC10967; UNQ3121/PRO10273; NILR; IL-21R; CD360; IL21R

G7Q0S8

EGM_11593

Human Cells

A DNA sequence encoding the cynomolgus IL21R (XP_005591578.1) (Met1-Pro236) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus IL21R sequences are identical.

Cynomolgus

The recombinant cynomolgus IL21R consists 458 amino acids and predicts a molecular mass of 52 kDa.

> 90 % as determined by SDS-PAGE.

1. Measured by its binding ability in a functional ELISA.
2. Immobilized human IL21 (Cat:501827) at 10 μg/mL (100 μL/well) can bind Cynomolgus IL21R-Fc. The EC₅₀ of Cynomolgus IL21R-Fc is 0.11-0.25 μg/mL.