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Cynomolgus IL-21R (His Tag) recombinant protein

Cat.#: 500742

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Product Information

  • Product Name
    Cynomolgus IL-21R (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. Interleukin-21 (IL-21) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL-21R) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL-4RA). The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.
  • Protein name
    Interleukin-21 receptor
  • Protein short names
    NILR; UNQ3121/PRO10273; IL21R; CD360; MGC10967; IL-21R
  • Uniprot ID
    G7Q0S8
  • Gene Name
    EGM_11593
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus IL21R (XP_005591578.1) (Met1-Pro236) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus IL21R comprises 228 amino acids and has a calculated molecular mass of 26.4 KDa. The apparent molecular mass of it is approximately 44.5 KDa in SDS-PAGE.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Cynomolgus IL-21R / Interleukin-21 Receptor Protein (His Tag) SDS-PAGE

    Cynomolgus IL-21R / Interleukin-21 Receptor Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"