Human IL-21R (His Tag) recombinant protein

Human IL-21R (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

This is a receptor for interleukin-21.

Interleukin-21 receptor

CD360; IL21R; NILR; UNQ3121/PRO10273; IL-21R; MGC10967

Q9HBE5

IL21R; NILR; UNQ3121/PRO10273

Human Cells

A DNA sequence encoding the human IL21R (Q9HBE5-1) extracellular domain (Met 1-Pro 236) was expressed, with a polyhistidine tag at the C-terminus.

Human

The recombinant human IL21R consists of 228 amino acids and predictes a molecular mass of 26.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL21R is approximately 42-46 kDa due to glycosylation.

> 92 % as determined by SDS-PAGE

1. Measured by its ability to bind human IL-21 in a functional ELISA.
2. Measured by its ability to inhibit IL21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED₅₀ for this effect is typically 1-5 ng/ml in the presence of 10 ng/ml of recombinant human IL21.
3. Measured by its ability to inhibit IL21 induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED₅₀ for this effect is typically 50-200 pg/mL in the presence of 1 ng/ml of recombinant human IL21.