CXCR4 Polyclonal Antibody

Cat.#: 161118

Special Price 174.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    CXCR4 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to CXCR4
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    CXCR4 antibody; CD184 antibody; D2S201E antibody; FB22 antibody; HM89 antibody; HSY3RR antibody; LAP-3 antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; NPY3R antibody; NPYR antibody; NPYRL antibody; NPYY3R antibody; WHIM antibody; WHIMS antibody; C-X-C chemokine receptor type 4 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-42 of human CXCR4 (NP_001008540.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • Validations

    Western blot - CXCR4 Polyclonal Antibody

    Western blot - CXCR4 Polyclonal Antibody

    Western blot analysis of extracts of THP-1 cells, using CXCR4 Antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 60s.

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human prostate using CXCR4 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat lung using CXCR4 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat brain using CXCR4 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry - CXCR4 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse stomach using CXCR4 antibody at dilution of 1:100 (40x lens).

  • Background
    Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).; (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"