CXCR4 Polyclonal Antibody

Cat.#: 162447

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Product Information

  • Product Name
    CXCR4 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to CXCR4
  • Tested applications
    IF
  • Species reactivity
    Human
  • Alternative names
    CXCR4 antibody; CD184 antibody; D2S201E antibody; FB22 antibody; HM89 antibody; HSY3RR antibody; LAP-3 antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; NPY3R antibody; NPYR antibody; NPYRL antibody; NPYY3R antibody; WHIM antibody; WHIMS antibody; C-X-C chemokine receptor type 4 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CXCR4 (NP_003458.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IF 1:50 - 1:200
  • Validations

    Immunofluorescence - CXCR4 Polyclonal Antibody

    Immunofluorescence - CXCR4 Polyclonal Antibody

    Immunofluorescence analysis of HeLa cells using CXCR4 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

  • Background
    Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).; (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"