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  • CSK antibody
  • CSK antibody

CSK antibody

Cat.#: 107179

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Product Information

  • Product Name
    CSK antibody
  • Documents
  • Description
    CSK Mouse Monoclonal antibody. Positive IF detected in A431 cells. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 50 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    C Src kinase antibody; c src tyrosine kinase antibody; CSK antibody; Protein tyrosine kinase CYL antibody; Tyrosine protein kinase CSK antibody
  • Isotype
    Mouse IgG2b
  • Preparation
    This antibody was obtained by immunization of CSK recombinant protein (Accession Number: BC106073). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:107179(CSK antibody) at dilution of 1:1000

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:107179(CSK antibody) at dilution of 1:1000

    Immunofluorescent analysis of A431 cells using Catalog No:107179(CSK Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IgG

    Immunofluorescent analysis of A431 cells using Catalog No:107179(CSK Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IgG

  • Background
    CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"