CSK antibody

CSK antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CSK Mouse Monoclonal antibody. Positive IF detected in A431 cells. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 50 kDa

ELISA, WB, IF

Human; other species not tested.

C Src kinase antibody; c src tyrosine kinase antibody; CSK antibody; Protein tyrosine kinase CYL antibody; Tyrosine protein kinase CSK antibody

Mouse IgG2b

This antibody was obtained by immunization of CSK recombinant protein (Accession Number: NM_001354988). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701).