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Product Name
Mouse CD146/MCAM (His Tag) recombinant protein
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Description
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
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Protein name
Cell surface glycoprotein MUC18
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Protein short names
MUC18; GICERIN; S-GICERIN; CD146; AV025631; MCAM; CD149; 1-GICERIN; S-ENDO
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Uniprot ID
Q8R2Y2
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Gene Name
Mcam; Muc18
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse MCAM (Q8R2Y2-1) extracellular domain (Met 1-Val 563) was expressed, fused with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse MCAM comprises 551 amino acids and has a calculated molecular mass of 61.3 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 90-100 kDa in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Validations
Mouse CD146 / MCAM Protein (His Tag) SDS-PAGE
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