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Product Name
Human CDC42 (GST Tag) recombinant protein
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Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
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Protein name
Cell division control protein 42 homolog
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Protein short names
RP23-246F18.2; AU018915; RP1-224A6.5; G25K; CDC42HS; AI747189; CDC42
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Uniprot ID
P60953
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Gene Name
CDC42
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human CDC42 isoform 2 (P60953-2) (Met 1-Cys 188) was fused with the GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CDC42/GST chimera consists of 423 amino acids and has a predicted molecular mass of 48.1 kDa. It migrates as an approxiamtely 44 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human CDC42 / G25K Protein (GST Tag) SDS-PAGE
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