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Product Name
Rat CD63 / Tspan-30 / Tetraspanin-30 (His Tag) recombinant protein
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Description
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
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Protein name
CD63 antigen
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Protein short names
MLA1; MGC107286; TSPAN30; ME491; LAMP-3; C75951; OMA81H; CD63; MGC103180
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Uniprot ID
P28648
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Gene Name
Cd63
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat CD63 (P28648) (Ala103-Val203) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat CD63 comprises 121 amino acids and has a predicted molecular mass of 13.8 kDa. The apparent molecular mass of the protein is approximately 24, 19, 15 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
(25.6+25.0+35.9) % as determined by SDS-PAGE
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Validations
Rat CD63 / Tspan-30 / Tetraspanin-30 Protein (His Tag) SDS-PAGE
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