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Product Name
Human CD63 / Tspan-30 / Tetraspanin-30 (His Tag) recombinant protein
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Description
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
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Protein name
CD63 antigen
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Protein short names
ME491; TSPAN30; C75951; OMA81H; LAMP-3; MLA1; MGC107286; CD63; MGC103180
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Uniprot ID
P08962
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Gene Name
CD63; MLA1; TSPAN30
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the second extracellular domain of human CD63 (P08962-1) (Ala 103-Val 203) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD63 consists of 112 amino acids after removal of the signal peptide and has a predicted molecular mass of 13 kDa. The apparent molecular mass of rh CD63 is approximately 20-25 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human CD63 / Tspan-30 / Tetraspanin-30 Protein (His Tag) SDS-PAGE
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