Human CD200R1 (His Tag) recombinant protein

Human CD200R1 (His Tag) recombinant protein

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The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal.

CD200R1 protein

HCRTR2; CD200R1; CD200R; OX2R; MOX2R

B7ZKV2

CD200R1

Human Cells

A DNA sequence encoding the human CD200R1 (AAI43394.1) extracellular domain (Met 1-Leu 266) was fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human CD200R1 comprises 251 amino acids after removal of the signal peptide and has a predicted molecular mass of 28.2 kDa. As a result of glycosylation, rh CD200R1 migrates as an approximately 50-60 kDa band in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized human CD200R1 at 1 μg/ml (100 μl/well) can bind human CD200 with a linear range of 0.12-16 ng/ml.