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Product Name
Mouse CD200R1 (His & Fc Tag) recombinant protein
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Description
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.
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Protein name
Cell surface glycoprotein CD200 receptor 1
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Protein short names
CD200R; OX2R; MOX2R; HCRTR2; CD200R1
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Uniprot ID
Q9ES57
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Gene Name
Cd200r1; Mox2r; Ox2r
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Pro 238) of mouse CD200R1 (NP_067300.1) precursor was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CD200R1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 462 amino acids and has a predicted molecular mass of 51.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCD200R1/Fc monomer is approximately 90-100 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse CD200 at 1 μg/ml (100 μl/well) can bind mouse CD200R1/Fc with a linear range of 1.5-200 ng/ml.
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Validations
Mouse CD200R1 Protein (His & Fc Tag) SDS-PAGE
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