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Product Name
Human CD180/RP105 (His Tag) recombinant protein
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Description
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
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Protein name
CD180 antigen
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Protein short names
MGC126233; CD180; LY64; LY78; RP105; F630107B15; MGC126234
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Uniprot ID
Q99467
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Gene Name
CD180; LY64; RP105
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD180 (NP_005573.2) extracellular domain (Met 1-Gly 626) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD180 consists of 614 amino acids and predictes a molecular mass of 69 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCD180 is approximately 90-100 kDa due to glycosylation.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD180 at 2 μg/ml (100 μl/well) can bind biotinylated mouse MD-1 with a linear ranger of 3.125-25 μg/ml.
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Validations
Human CD180 / RP105 / LY64 Protein (His Tag) SDS-PAGE
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