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Human beta-Catenin/CTNNB1 (His & GST Tag) recombinant protein

Cat.#: 502916

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Product Information

  • Product Name
    Human beta-Catenin/CTNNB1 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
  • Protein name
    Catenin beta-1
  • Protein short names
    OK/SW-CL.35; MRD19; MESC; CTNNB; ARMADILLO; CATENIN BETA-1; DKFZP686D02253; CATNB; BFC; FLJ25606; FLJ37923; CTNNB1; BETA-CATENIN
  • Uniprot ID
    P35222
  • Gene Name
    CTNNB1; CTNNB; OK/SW-cl.35; PRO2286
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CTNNB1 (P35222-1) (Met 1-Leu 781) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CTNNB1/GST chimera consists of 1018 amino acids and has a calculated molecular mass of 113 kDa. It migrates as an approximately 116 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 87 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind biotinylated mouse ERBB2 in a functional ELISA.
  • Validations

    Human beta-Catenin / CTNNB1 Protein (His & GST Tag) SDS-PAGE

    Human beta-Catenin / CTNNB1 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"