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Anti-beta Catenin (7E2) Mouse antibody

Cat.#: 168202

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-beta Catenin (7E2) Mouse antibody
  • Documents
  • Description
    beta Catenin (7E2) Mouse monoclonal antibody
  • Tested applications
    WB, ICC/IF, IHC-P
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Recombinant Protein of Catenin-β
  • Clonality
    Monoclonal
  • Formulation
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-2000

    IHC: 1/200-500

    IF: 1/200

  • Validations

    Western blot analysis of 1) Hela, 2) 293T, 3)Mouse Liver Tissue, 4) Rat Liver Tissue, with β-Catenin Mouse mAb diluted at 1:2,000.

    Western blot analysis of 1) Hela, 2) 293T, 3)Mouse Liver Tissue, 4) Rat Liver Tissue, with β-Catenin Mouse mAb diluted at 1:2,000.

    Western blot detection of β-Catenin in T47D,3T3,COS7 and C6 cell lysates using β-Catenin mouse mAb (1:3000 diluted).Predicted band size:92KDa.Observed band size:92KDa.

    Western blot detection of β-Catenin in T47D,3T3,COS7 and C6 cell lysates using β-Catenin mouse mAb (1:3000 diluted).Predicted band size:92KDa.Observed band size:92KDa.

  • Background
    Swiss-Prot Acc.P35222.Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle .

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"