-
Product Name
Canine CD40/TNFRSF5 (His Tag) recombinant protein
- Documents
-
Description
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
-
Protein name
Tumor necrosis factor receptor superfamily member 5
-
Protein short names
P50; CDW40; AI326936; IMD3; T-BAM; IGM; HIGM1; CD40; TNFRSF5; BP50; GP39; MGC9013; RP23-428M13.1; TRAP
-
Uniprot ID
Q7YRL5
-
Gene Name
CD40; TNFRSF5
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the canine CD40 (Q7YRL5) (Met1-Ala194) was expressed with a C-terminal polyhistidine tag.
-
Protein Species
Canine
-
Molecular weight
The recombinant canine CD40 comprises 185 amino acids and has a predicted molecular mass of 20.5 kDa. The apparent molecular mass of the protein is approximately 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Canine CD40 / TNFRSF5 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"