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Product Name
Canine CD40/TNFRSF5 (Fc Tag) recombinant protein
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Description
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
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Protein name
Tumor necrosis factor receptor superfamily member 5
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Protein short names
P50; CDW40; IMD3; AI326936; T-BAM; IGM; HIGM1; CD40; TNFRSF5; BP50; GP39; MGC9013; RP23-428M13.1; TRAP
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Uniprot ID
Q7YRL5
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Gene Name
CD40; TNFRSF5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine CD40 (Q7YRL5) (Met1-Ala194) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine CD40/Fc is a disulfide-linked homodimer. The reduced monomer comprises 415 amino acids and has a predicted molecular mass of 46.1 kDa. The apparent molecular mass of the protein is approximately 50-56 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Canine CD40 / TNFRSF5 Protein (Fc Tag) SDS-PAGE
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