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Product Name
Mouse CLEC10A/MGL1/CD301 (Fc Tag) recombinant protein
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Description
CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.
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Protein name
C-type lectin domain family 10 member A
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Protein short names
CD301A; MGL1; HML2; M-ASGP-BP-1; CLECSF14; CLECSF13; CD301; CLEC10A; DN-160I24.1; HML; MGL
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Uniprot ID
F8WHB7
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Gene Name
Clec10a
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CLEC10A (NP_001191181.1) (Gln 58-Ser 305) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse CLEC10A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 508 amino acids and predicts a molecular mass of 56.7 kDa. The apparent molecular mass of the monomer is approximately 58 kDa in SDS-PAGE under reducing conditions.
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Purity
> 86 % as determined by SDS-PAGE
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Validations
Mouse CLEC10A / MGL1 / CD301 Protein (Fc Tag) SDS-PAGE
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