-
Product Name
Mouse CLEC10A/MGL1/CD301 (His Tag) recombinant protein
- Documents
-
Description
CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL)-10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.
-
Protein name
C-type lectin domain family 10 member A
-
Protein short names
M-ASGP-BP-1; HML2; MGL1; CD301A; CLEC10A; CD301; CLECSF13; CLECSF14; MGL; HML; DN-160I24.1
-
Uniprot ID
F8WHB7
-
Gene Name
Clec10a
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CLEC10A (NP_001191181.1) (Gln 58-Ser 305) was fused with a polyhistidine tag at the N-terminus.
-
Protein Species
Mouse
-
Molecular weight
The recombinant mouse CLEC10A comprises 267 amino acids and predicts a molecular mass of 30.7 kDa. The apparent molecular mass of mouse CLEC10A is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
-
Purity
> 97 % as determined by SDS-PAGE
-
Validations
Mouse CLEC10A / MGL1 / CD301 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"