-
Product Name
Rat C-Reactive Protein/CRP (His Tag)
- Documents
-
Description
C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.
-
Protein name
C-reactive protein, pentraxin-related
-
Protein short names
RP11-419N10.4; PTX1; C-REACTIVE PROTEIN; AI255847; PENTRAXIN 1; MGC88244; MGC149895; CRP
-
Uniprot ID
P48199
-
Gene Name
Crp; crp; rCG_20135
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rat CRP (NP_058792.1) extracellular domain (Met 1-Ser 230) was fused with a polyhistidine tag at the C-terminus.
-
Protein Species
Rat
-
Molecular weight
The recombinant rat CRP comprises 221 amino acids and predicts a molecular mass of 24.6 kDa. The apparent molecular mass of the rat CRP is approximately 30 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 97 % as determined by SDS-PAGE
-
Validations
Rat CRP / C-Reactive Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"