Human C-Reactive Protein/CRP (His Tag)

Human C-Reactive Protein/CRP (His Tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

C-reactive protein

CRP; MGC149895; MGC88244; PENTRAXIN 1; AI255847; C-REACTIVE PROTEIN; PTX1; RP11-419N10.4

P02741

CRP; PTX1

Human Cells

A DNA sequence encoding the human CRP (NP_000558.2) (Met 1-Pro 224) was fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human CRP consists of 217 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of rhCRP is approximately 27 kDa in SDS-PAGE under reducing conditions.

> 92 % as determined by SDS-PAGE

Measured by its ability to bind human CD32a-His (Cat:503128) in functional ELISA.