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Product Name
Human CCL21/6Ckine recombinant protein
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Description
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
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Protein name
C-C motif chemokine 21
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Protein short names
MGC107632; 6CKBAC2; CKB9; 6CKINE; ECL; TCA4; CCL21; SLC; RP11-195F19.22-001; CCL21A; ALP; AW987545; SCYA21B; RP23-411B7.4; SCYA21A; SCYA21; MGC34555
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Uniprot ID
O00585
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Gene Name
CCL21; SCYA21; UNQ784/PRO1600
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CCL21 (O00585) (Met 1-Pro 134) was expressed and purified.
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Protein Species
Human
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Molecular weight
The secreted recombinant human CCL21 consists of 111 amino acids and predicts a molecular mass of 12.3 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human CCL21 at 2 μg/ml (100 μl/well) can bind human IGFBP7 with a linear ranger of 0.16-4 μg/ml.
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Validations
Human CCL21 / 6Ckine Protein SDS-PAGE
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