Anti-CCL21/6Ckine antibody

Anti-CCL21/6Ckine antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CCL21/6Ckine

ELISA, WB

Cynomolgus CCL21 / SCYA21

6CKBAC2 antibody; 6Ckine antibody; 6Ckine antibody; ALP antibody; AW987545 antibody; CCL21 antibody; Ccl21a antibody; CKb9 antibody; CKb9 antibody; ECL antibody; MGC107632 antibody; MGC34555 antibody; RP11-195F19.22-001 antibody; RP23-411B7.4 antibody; SCYA21 antibody; Scya21 antibody; SCYA21a antibody; Scya21b antibody; SLC antibody; SLC antibody; TCA4 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Cynomolgus CCL21 / SCYA21 (Q8HYP5; Met1-Pro131). CCL21 / SCYA21 specific IgG was purified by Cynomolgus CCL21 / SCYA21 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 21(CCL21), also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine(SLC), is a small cytokine belonging to the C-C chemokine family. CCL21 takes its name 6Ckine for its consititutively six conserved cysteine residues but not four cysteines typical to chemokines. CCL21 has function in ininducing vigorous calcium migrations and chemotactic responses.

• Laing KJ, et al. (2004) Chemokines. Developmental and comparative immunology. 28(5): 443-60.
• Cocchi F, et al. (1995) Identification of RANTES, MIP-1a, and MIP-1b as the major HIV-suppressive factor produced by CD8⁺ T cells. Science. 270 (5243): 1811-5.
• Yoshida R, et al. (1998) Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. The journal of biological chemistry. 273: 7118-22.