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Product Name
Mouse NGF / NGFB recombinant protein
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Description
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
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Protein name
Beta-nerve growth factor
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Protein short names
BETA-NGF; NGF; MGC161428; HSAN5; MGC161426; NGFB
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Uniprot ID
P01139
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Gene Name
Ngf; Ngfb
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of mouse NGF (NP_001106168.1) (Ser 122-Gly 241) was expressed, with an initial Met at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse NGF consists of 121 amino acids and has a calculated molecular mass of 13.5 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED50 for this effect is 0.2-2ng/mL. -
Validations
Mouse ?-NGF / Beta-NGF Protein SDS-PAGE
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"