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Product Name
Human NGF / NGFB recombinant protein
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Description
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
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Protein name
Beta-nerve growth factor
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Protein short names
MGC161428; NGF; BETA-NGF; NGFB; MGC161426; HSAN5
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Uniprot ID
P01138
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Gene Name
NGF; NGFB
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Source/Expression Host
CHO Stable Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human ?-NGF (NP_002497.2) (Ser 122-Arg 239) was expressed.
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Protein Species
Human
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Molecular weight
The mature recombinant human ?-NGF consists of 118 amino acids and has a predicted molecular mass of 13.2 kDa. ?-NGF exists as a non-disulfide linked homodimer in solution.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-2 ng/ml.
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Validations
Human ?-NGF / Beta-NGF Protein SDS-PAGE
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