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Product Name
Mouse CD147/EMMPRIN (His & Fc Tag) recombinant protein
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Description
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
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Protein name
Basigin
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Protein short names
EMMPRIN; AI325119; CD147; BSG; AI115436; HT-7; 5F7; TCSF; OK; BASIGIN; M6
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Uniprot ID
P18572
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Gene Name
Bsg
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse BSG isoform 2 (NP_001070652.1) (Met 1-Arg 209) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse BSG/Fc is a disulfide-linked homodimer The reduced monomer comprises 436 amino acids and has a predicted molecular mass of 48.6 kDa. As a result of glycosylation, it migrates as an approximately 60-70 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Using the Octet RED System, the affinity constant (Kd) of mouse CD147-Fc (Cat:502212) bound to Human PPIA-His (Cat:501254) was 0.4 μM.
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Validations
Mouse CD147 / EMMPRIN / Basigin Protein (His & Fc Tag) SDS-PAGE
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