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Aurora B antibody

Cat.#: 107073

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Product Information

  • Product Name
    Aurora B antibody
  • Documents
  • Description
    Aurora B Mouse Monoclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in HeLa cells, mouse thymus tissue. Observed molecular weight by Western-blot: 39-45 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    AIK2 antibody; AIM 1 antibody; AIM1 antibody; ARK 2 antibody; ARK2 antibody; AurB antibody; AURKB antibody; Aurora B antibody; aurora kinase B antibody; Aurora related kinase 2 antibody; Aurora/IPL1 related kinase 2 antibody; IPL1 antibody; STK 1 antibody; STK12 antibody; STK5 antibody
  • Isotype
    Mouse IgG2b
  • Preparation
    This antibody was obtained by immunization of Aurora B recombinant protein (Accession Number: BC013300). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:107073(AURKB antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:107073(AURKB antibody) at dilution of 1:500

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:107073(AURKB Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:107073(AURKB Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:107073(AURKB Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using Catalog No:107073(AURKB Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

  • Background
    Aurora B(AURKB) is also named as aurora kinase B, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5 and belongs to the Aurora subfamily. Aurora kinase B is a chromosomal passenger serine/threonine protein kinase that regulates accurate chromosomal segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint(PMID:18311747). Expression levels of AURKB are increased in the anaplastic thyroid carcinoma cell lines ARO, Cal 62, and KAT-4(PMID:15562011).
  • References
    • Aravindan S, Delma CR, Thirugnanasambandan SS, Herman TS, Aravindan N. Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae. PloS one. 8(4):e61977. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"