-
Product Name
Anti-WDR1 Rabbit antibody
- Documents
-
Description
WDR1 Rabbit monoclonal antibody
-
Tested applications
WB, IHC-P, ICC/IF
-
Species reactivity
Human, Mouse, Rat
-
Alternative names
AIP1; NORI-1; HEL-S-52 antibody
-
Isotype
Rabbit IgG
-
Preparation
Antigen: A synthetic peptide of human WDR1
-
Clonality
Monoclonal
-
Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
Applications
WB: 1/1000-1/5000
IHC: 1/20-1/50
ICC/IF: 1/20-1/50
-
Validations
Western blot detection of WDR1 in Jurkat cell lysates using WDR1 Rabbit mAb(1:500 diluted).Predicted band size:66kDa.Observed band size:66kDa.
-
Background
Swiss-Prot Acc.O75083.Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"