Anti-RhoGDI Rabbit antibody

Cat.#: 168955

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Product Information

  • Product Name
    Anti-RhoGDI Rabbit antibody
  • Documents
  • Description
    RhoGDI Rabbit monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human RhoGDI
  • Clonality
    Monoclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of RhoGDI in K562,Rat Brain,C6,3T3,Hela cell lysates using RhoGDI Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:26kDa.

    Western blot detection of RhoGDI in K562,Rat Brain,C6,3T3,Hela cell lysates using RhoGDI Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:26kDa.

  • Background
    Swiss-Prot Acc.P52565.Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"