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Product Name
Anti-PTN Rabbit antibody
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Description
PTN Rabbit polyclonal antibody
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Tested applications
WB, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
HARP; HBBM; HBNF; HBGF8; NEGF1; OSF-1; HB-GAM; HBGF-8; HBNF-1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human PTN
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
IP: 1/20
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Validations
Western blot detection of PTN in C6,Rat Brain cell lysates using PTN Rabbit pAb(1:1000 diluted).Predicted band size:19kDa.Observed band size:19kDa.
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Background
Swiss-Prot Acc.P21246.Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"