Anti-PTN antibody

Anti-PTN antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Mouse PTN

WB, IHC-P

Mouse Pleiotrophin / PTN / HB-GAM

HBGF-8 antibody; HBGF-8 antibody; HBNF antibody; HBNF antibody; HBNF-1 antibody; heparin affin regulatory peptide antibody; heparin affin regulatory protein antibody; NEGF1 antibody; OSF antibody; Osf1 antibody; Osf-1 antibody; OSF-1 antibody; HBNF antibody; HBGF8 antibody; NEGF1 antibody; OSF antibody; HARP antibody; HBBN antibody; HBNF antibody; Osf1 antibody; Osf-1 antibody; HB-GAM antibody; HBGF-8 antibody; HARP antibody; HARP antibody; HARP antibody; HBBM antibody; HBBM antibody; HBBN antibody; HB-GAM antibody; HB-GAM antibody; HBGF8 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse Pleiotrophin / PTN / HB-GAM . Pleiotrophin / PTN / HB-GAM specific IgG was purified by Mouse Pleiotrophin / PTN / HB-GAM affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.