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Product Name
Mouse Pleiotrophin / PTN / HB-GAM (Fc Tag) recombinant protein
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Description
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (By similarity).
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Protein name
Pleiotrophin
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Protein short names
HBNF-1; HBNF; HARP; OSF-1; HEPARIN AFFIN REGULATORY PROTEIN; OSF; HBGF8; NEGF1; HBGF-8; HEPARIN AFFIN REGULATORY PEPTIDE; OSF1; HB-GAM; HBBM; HBBN
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Uniprot ID
P63089
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Gene Name
Ptn
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse PTN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 396 amino acids and has a calculated molecular mass of 43.7 kDa. The apparent molecular mass of the monomer is approximately 47 kDa in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Mouse Pleiotrophin / PTN / HB-GAM Protein (Fc Tag) SDS-PAGE
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